On facilitated oxygen diffusion in muscle tissues
نویسندگان
چکیده
منابع مشابه
Myoglobin facilitated oxygen diffusion maintains mechanical function of mammalian cardiac muscle.
Myoglobin, an intracellular iron containing protein that binds oxygen reversibly, has been shown in model systems to facilitate the diffusion of oxygen and thereby maintain the mechanical function of exercising canine skeletal muscle and of hypoxic benthic fish hearts. Since no such role has yet been established for mammalian cardiac muscle small diameter (less than or equal to 0.70 mm) isolate...
متن کاملHemoglobin-facilitated diffusion of oxygen: interfacial and thickness effects.
The equations of facilitated diffusion were solved numerically for steady state diffusion of oxygen across membranes of hemoglobin and myoglobin. An interfacial resistance was included in the boundary conditions and the dependence of the solutions on membrane thickness and interfacial conductance was studied. The data of Wittenberg on millipore membranes was fitted adequately if a tortuosity fa...
متن کاملFacilitated diffusion on confined DNA.
In living cells, proteins combine three-dimensional bulk diffusion and one-dimensional sliding along the DNA to reach a target faster. This process is known as facilitated diffusion and we investigate its dynamics in the physiologically relevant case of confined DNA. The confining geometry and DNA elasticity are key parameters: We find that facilitated diffusion is most efficient inside an isot...
متن کاملThe molecular mechanism of hemoglobin-facilitated oxygen diffusion.
Hemoglobin in solution augments the rate of steady state diffusion of oxygen. The flux of oxygen exceeds the diffusive flux by an amount, the facilitated flux, which is constant for a given hemoglobin concentration and is invariant with changing oxygen tension. The facilitated flux is inversely proportional to the length of the diffusion path. Facilitation decreases with increasing molecular si...
متن کاملFacilitated diffusion of proteins on chromatin.
We present a theoretical model of facilitated diffusion of proteins in the cell nucleus. This model, which takes into account the successive binding and unbinding events of proteins to DNA, relies on a fractal description of the chromatin which has been recently evidenced experimentally. Facilitated diffusion is shown quantitatively to be favorable for a fast localization of a target locus by a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1980
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(80)85145-9